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Curr Opin Cell Biol. 2007 Aug;19(4):394-401. Epub 2007 Jul 12.

Lysosome-related organelles: driving post-Golgi compartments into specialisation.

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1
Institut Curie, Centre de Recherche, Paris F-75248, France. graca.roposo@curie.fr

Abstract

Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.

PMID:
17628466
PMCID:
PMC2782641
DOI:
10.1016/j.ceb.2007.05.001
[Indexed for MEDLINE]
Free PMC Article
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