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J Physiol Paris. 2006 Nov-Dec;100(5-6):284-9. Epub 2007 Jun 8.

The pre-Bötzinger oscillator in the mouse embryo.

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Neurobiologie Génétique et Intégrative, Institut de Neurobiologie Alfred Fessard, CNRS, 1 av. de la terrasse, 91198 Gif sur Yvette, France.


Studies of the sites and mechanisms involved in mammalian respiratory rhythm generation point to two clusters of rhythmic neurons forming a coupled oscillator network within the brainstem. The location of these oscillators, the pre-Bötzinger complex (preBötC) at vagal level, and the para-facial respiratory group at facial level, probably result from regional patterning schemes specifying neural types in the hindbrain during embryogenesis. Here, we report evidence that the preBötC oscillator (i) is first active at embryonic stages, (ii) originates in the post-otic hindbrain neural tube and (iii) requires the glutamate vesicular transporter 2 for rhythm generation.

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