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Protein Pept Lett. 2007;14(6):557-64.

Interaction profiling of T-cell epitopes with MHC-class I molecules.

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Bioinformatics Centre and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore, India.


A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide-HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.

[Indexed for MEDLINE]

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