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Nat Rev Immunol. 2007 Aug;7(8):610-21. Epub 2007 Jul 13.

Tolerogenic dendritic cells and the quest for transplant tolerance.

Author information

1
Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. morelli@imap.pitt.edu

Abstract

In recent years, there has been a shift from the perception of dendritic cells (DCs) solely as inducers of immune reactivity to the view that these cells are crucial regulators of immunity, which includes their ability to induce and maintain tolerance. Advances in our understanding of the phenotypical and functional plasticity of DCs, and in our ability to manipulate their development and maturation in vitro and in vivo, has provided a basis for the therapeutic harnessing of their inherent tolerogenicity. In this Review, we integrate the available information on the role of DCs in the induction of tolerance, with a focus on transplantation.

PMID:
17627284
DOI:
10.1038/nri2132
[Indexed for MEDLINE]

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