Format

Send to

Choose Destination
Respiration. 2008;75(3):296-303. Epub 2007 Jul 12.

Exercise endurance before and after long-term noninvasive ventilation in patients with chronic respiratory failure.

Author information

1
Krankenhaus Oststadt-Heidehaus, Klinikum Region Hannover, Hannover, Germany. Bernd.Schoenhofer@t-online.de

Abstract

BACKGROUND:

Noninvasive mechanical ventilation (NIV) is known to reduce hypoventilation and improves respiratory and peripheral muscle endurance in patients with chronic respiratory failure (CRF) due to thoracic restriction.

OBJECTIVES:

To compare the effect of short-term NIV on endurance in patients with CRF due to thoracorestriction and chronic obstructive pulmonary disease (COPD) and to evaluate differences in spiroergometric data during exercise testing.

METHODS:

Thirty-five patients with CRF due to COPD and 24 patients with CRF due to thoracorestriction entered the trial. Constant work rate exercise testing at 75% of the maximal workload, pulmonary function and arterial blood gas testing were performed before and after 3 months of NIV. Measurements were compared between and within groups.

RESULTS:

The non-COPD group increased their exercise time significantly from 4.7 +/- 1.81 to 6.59 +/- 3.15 min (p = 0.0032). There was no change in the COPD group (4.57 +/- 2.19 min before and 5.39 +/- 3.09 min after NIV, p = 0.09). CO(2) levels at rest fell in both groups (COPD 52.30 +/- 7.77 to 46.06 +/- 4.61 mm Hg and non-COPD 47.82 +/- 5.19 to 43.79 +/- 4.15 mm Hg). While COPD patients increased their minute ventilation (13.47 +/- 2.73 to 14.88 +/- 2.67 l/min), non-COPD patients decreased their oxygen uptake from 6.27 +/- 1.61 to 5.54 +/- 1.35 ml/kg.

CONCLUSIONS:

NIV improved endurance only in the non-COPD group. This and the reduction in CO(2) are achieved by lowering energetic requirements. COPD patients though decreased their resting CO(2) by increased minute ventilation.

PMID:
17627102
DOI:
10.1159/000105542
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center