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Rev Inst Med Trop Sao Paulo. 2007 May-Jun;49(3):201-2.

The use of the antifungal agent miconazole as an inhibitor of Blastocystis hominis growth in Entamoeba histolytica/E. dispar cultures.

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1
Laboratório de Doenças Parasitárias, Departamento de Medicina Tropical, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil. queiroga@ioc.fiocruz.br

Abstract

In regions with high prevalence, Blastocystis hominis is frequently found in association with Entamoeba histolytica/E. dispar in xenic cultures. Its exacerbated growth is often superimposed on the growth of amebas, thus impeding the continuation of the amebas in the culture, within a few generations. The present study reports on the excellent efficacy (100%) of the antifungal agent miconazole in eliminating B. hominis from cultures of E. histolytica/E. dispar, thereby maintaining the integrity of the trophozoites of the amebas. Nystatin presented low efficacy (33.3%).

PMID:
17625701
[Indexed for MEDLINE]
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