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J Pediatr (Rio J). 2007 Jul-Aug;83(4):319-22. doi: 10.2223/JPED.1645. Epub 2007 Jul 11.

Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy.

Author information

1
Children's Hospital at Sanliurfa, Sanliurfa, Turkey. ayciceka@hotmail.com

Abstract

OBJECTIVE:

To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.

METHOD:

Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidative stress index (OSI) and individual oxidant components: malondialdehyde (MDA), and lipid hydroperoxide levels.

RESULTS:

Vitamin C, uric acid, total bilirubin and MDA concentration were significantly lower, whereas serum TOS, lipid hydroperoxide and OSI levels were significantly higher after phototherapy (p < 0.05). There were significant positive correlations between serum total bilirubin and MDA (r = 0.434, p = 0.001).

CONCLUSIONS:

Although the MDA level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress.

PMID:
17625638
DOI:
10.2223/JPED.1645
[Indexed for MEDLINE]
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