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J Infect Dis. 2007 Aug 15;196(4):537-40. Epub 2007 Jun 29.

Efficacy of the human rotavirus vaccine RIX4414 in malnourished children.

Author information

1
Instituto de Biomedicina-Fuvesin, Universidad Central de Venezuela, Ministerio de Salud, Caracas, Venezuela. ireneperezschael@cantv.net

Abstract

The effect of nutritional status on protective efficacy of a live attenuated human rotavirus vaccine (RIX4414) was studied. Vaccine protection was evaluated through a secondary analysis of data from an efficacy study conducted in Brazil, Mexico, and Venezuela. Vaccine efficacy against rotavirus gastroenteritis (RVGE) was similar in well-nourished and malnourished infants: 74.1% (95% confidence interval [CI], 52.2%-86.2%) and 73% (95% CI, 11.2%-92.3%) for severe RVGE and 60.9% (95% CI, 37.4%-75.4%) and 61.2% (95% CI, 10.4%-83.1%) for RVGE of any severity, respectively. RIX4414 significantly decreased the rate of RVGE regardless of nutritional status, which suggests that this patient group can also benefit from rotavirus vaccination.

CLINICAL TRIALS REGISTRY:

e-Track 444563-006, NCT00385320 (http://www.clinicaltrials.gov).

PMID:
17624838
DOI:
10.1086/519687
[Indexed for MEDLINE]

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