Format

Send to

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2007 Aug 15;196(4):528-36. Epub 2007 Jun 29.

Early evolution of hepatitis C virus (HCV) quasispecies after liver transplant for HCV-related disease.

Author information

  • 1Laboratoire de Virologie, Hopital Civil, Strasbourg, France. Evelyne.Schvoerer@chru-strasbourg.fr

Abstract

BACKGROUND:

End-stage liver disease as a result of chronic hepatitis C virus (HCV) infection is the main indication for liver transplant (LT), but allografts are systematically infected with HCV soon after transplant. Viral quasispecies are poorly described during the early posttransplant period.

METHODS:

For 17 patients who received an LT for HCV disease, plasma viral quasispecies evolution was determined by sequence analysis of hypervariable region 1 of the E2 envelope gene before transplant (BT), after 7 days (D7), and after 1 month (M1). T helper (Th)1/Th2 cytokine levels were determined concomitantly.

RESULTS:

HCV quasispecies showed a significant decrease in amino acid diversity at D7 and M1, compared with BT (P<.05). A correlation was observed between low plasma tumor necrosis factor-alpha levels at D7 and decreased quasispecies amino acid complexity at the same date. Nucleic acid diversity was lower for genotype 1 than for genotype 3 infection (P<.05). The complexity and diversity of amino acids were lower in patients with hepatocellular carcinoma (HCC) BT than in those without HCC (P<.05). Conserved amino acid residues within quasispecies were shared by the whole cohort before and after LT.

CONCLUSION:

Viral structural and/or host immunological features could favor the emergence of fitter HCV strains after LT.

PMID:
17624837
DOI:
10.1086/519691
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center