Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Immunopathol. 2007 Jun;29(2):185-91.

The remission of rheumatoid arthritis during pregnancy.

Author information

1
Clinic for Rheumatology and Clinical Immunology, University Hospital of Berne, CH-3010 Bern, Switzerland. monika.oestensen@insel.ch

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that is favorably influenced by pregnancy but relapses after delivery. A variety of circulating factors has been considered as candidates for inducing gestational improvement of RA; however, the factors/pathways responsible remain still elusive. This review discusses recent research on the effect of pregnancy on RA with a focus on immunregulation, cytokine secretion, HLA antigens, microchimerism, and innate immunity. The complex hormonal and immunological alterations of pregnancy may temporarily correct the disturbed immunregulation of RA.

PMID:
17621703
DOI:
10.1007/s00281-007-0072-5
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center