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Eur J Pharmacol. 2007 Sep 24;571(1):25-8. Epub 2007 Jun 5.

Therapeutic doses of amphetamine and methylphenidate selectively redistribute the vesicular monoamine transporter-2.

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1
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA. evan.riddle@pharm.utah.edu

Abstract

High-dose administration of psychostimulants traffics the vesicular monoamine transporter-2 (VMAT-2), as assessed by subcellular fractionation of rat striatal tissue. This study demonstrates that administration of low doses of amphetamine or methylphenidate differentially traffic VMAT-2 within nerve terminals, with effects similar to those observed after high-dose administration. Trafficking of vesicular glutamate, acetylcholine, or GABA transporters was not altered by high-or low-dose amphetamine or methylphenidate treatment. These data represent the first report that amphetamine redistributes VMAT-2 protein. In addition, these data demonstrate that the trafficking of VMAT-2 after amphetamine or methylphenidate is selective for monoaminergic neurons.

PMID:
17618619
PMCID:
PMC2581712
DOI:
10.1016/j.ejphar.2007.05.044
[Indexed for MEDLINE]
Free PMC Article

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