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Nat Genet. 2007 Aug;39(8):966-8. Epub 2007 Jul 8.

Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice.

Author information

1
Department of Cell and Molecular Biology, Karolinska Institutet, S-171 77, Stockholm, Sweden.

Abstract

The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes (univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes.

PMID:
17618286
DOI:
10.1038/ng2065
[Indexed for MEDLINE]

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