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Nat Neurosci. 2007 Aug;10(8):946-8. Epub 2007 Jul 8.

Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch.

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1
The Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 N. Wolfe St., Baltimore, Maryland 21205, USA.

Abstract

C-fiber tactile afferents are a subpopulation of unmyelinated cutaneous sensory neurons activated by gentle stroking. Using a genetically encoded tracer, we found that Mas-related G protein-coupled receptor B4 marks a rare subpopulation of unmyelinated, nonpeptidergic sensory fibers that exclusively innervate hairy skin. These fibers terminate in large arborizations similar in size and distribution to C-fiber tactile afferent receptive fields, suggesting that MrgprB4 may provide genetic access to these elusive neurons in mice.

PMID:
17618277
DOI:
10.1038/nn1937
[Indexed for MEDLINE]
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