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Biochim Biophys Acta. 2007 Oct;1768(10):2510-5. Epub 2007 Jun 12.

VDAC closure increases calcium ion flux.

Author information

1
Department of Biology, University of Maryland, College Park, MD 20742, USA.

Abstract

VDAC is the major permeability pathway in the mitochondrial outer membrane and can control the flow of metabolites and ions. Therefore Ca(2+) flux across the outer membrane occurs mainly through VDAC. Since both Ca(2+) fluxes and VDAC are involved in apoptosis, we examined whether Ca(2+) is required for channel formation by VDAC isolated from rat liver. The voltage gating of VDAC does not require Ca(2+) and it functions normally with or without Ca(2+). Additionally, VDAC generally shows a higher permeability to Ca(2+) in the closed states (states with lower permeability to metabolites) than that in the open state. Thus VDAC closure, which induces apoptosis, also favors Ca(2+) flux into mitochondria, which can also lead to permeability transition and cell death. These results are consistent with the view that VDAC closure is a pro-apoptotic signal.

PMID:
17617374
PMCID:
PMC2220155
DOI:
10.1016/j.bbamem.2007.06.002
[Indexed for MEDLINE]
Free PMC Article

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