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J Assist Reprod Genet. 2007 Jul;24(7):303-15.

Angiogenesis in implantation.

Author information

1
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, P.O. Box 19626, Springfield, IL 62794-9626, USA. dtorry@siumed.edu

Abstract

PROBLEM:

Implantation failure and early pregnancy loss are common following natural conceptions and they are particularly important clinical hurdles to overcome following assisted reproduction attempts. The importance of adequate vascular development and maintenance during implantation has recently become a major focus of investigation.

MATERIALS AND METHODS:

Review of current published literature was undertaken to summerize the cells and cell products that regulate tissue vascularity during implantation.

RESULTS:

Vascular development at the maternal fetal interface can be regulated by a number of different cell types; two principal candidates are trophoblast and natural killer cells. A wide range of soluble factors, some with well established angiogenic functions as well as other more novel factors, can contribute to vascular development and maintenance at the maternal-fetal interface.

CONCLUSIONS:

Robust vascular development occurs during implantation and early placentation of normal pregnancies. Studies to define the extent and mechanisms by which defects in vascularity contribute to human implantation failure and early miscarriage need to be undertaken.

PMID:
17616801
PMCID:
PMC3455012
DOI:
10.1007/s10815-007-9152-7
[Indexed for MEDLINE]
Free PMC Article
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