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Expert Opin Ther Targets. 2007 Jul;11(7):955-65.

FOXP1: a potential therapeutic target in cancer.

Author information

1
Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA, USA.

Abstract

Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its overexpression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.

PMID:
17614763
PMCID:
PMC4282158
DOI:
10.1517/14728222.11.7.955
[Indexed for MEDLINE]
Free PMC Article

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