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Eur J Cancer. 2007 Aug;43(12):1849-55. Epub 2007 Jul 5.

Does HPV-status 6-12 months after treatment of high grade dysplasia in the uterine cervix predict long term recurrence?

Author information

1
Department of Obstetrics & Gynaecology, Sahlgrenska Academy, University of Göteborg, SE-413 45 Göteborg, Sweden. bjorn.strander@oc.gu.se

Abstract

BACKGROUND:

Women once treated for high grade cervical dysplasia have a high long term risk for developing new dysplasia or cancer.

OBJECTIVES:

To investigate if human papilloma virus (HPV)-negativity after treatment of cervical dysplasia reduces the need for frequent long term follow up.

DESIGN:

Case/control study based on archival smears.

METHODS:

Women with cervical intraepithelial neoplasi (CIN)2-3, treated for dysplasia and with recurrence of CIN2+ more than 2 years after treatment were compared with controls without recurrence, matched for age and date of treatment. High risk-HPV-DNA were analysed with PCR from two archival smears per woman. Mean follow up time was 14.6 years.

RESULTS:

24% (45/189) of cases and 11% (43/378) of controls were HPV-positive in any of two smears. Odds ratio (OR)=2.5 (1.6-3.8).

CONCLUSION:

HPV-status 6-12 months after treatment of high grade dysplasia is of limited value for the design of long term follow up.

PMID:
17614272
PMCID:
PMC2933034
DOI:
10.1016/j.ejca.2007.05.016
[Indexed for MEDLINE]
Free PMC Article

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