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Brief Bioinform. 2007 Sep;8(5):294-303. Epub 2007 Jul 4.

Informatics challenges in structured RNA.

Author information

1
Department of Genetics, 300 Pasteur Drive, Stanford University, Stanford, CA 94305, USA. alain@helix.stanford.edu

Abstract

The world of regulatory RNAs is fast expanding into mainstream molecular biology as both a subject of intense mechanistic study and as a tool for functional characterization. The RNA world is one of complex structures that carry out catalysis, sense metabolites and synthesize proteins. The dynamic and structural nature of RNAs presents a whole new set of informatics challenges to the computational community. The ability to relate structure and dynamics to function will be key to understanding this complex world. I review several important classes of structured RNAs that present our community with a series of biologically novel informatics challenges. I also review available informatics tools that have been recently developed in the field.

PMID:
17611237
PMCID:
PMC2629073
DOI:
10.1093/bib/bbm026
[Indexed for MEDLINE]
Free PMC Article

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