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Neuron. 2007 Jul 5;55(1):1-2.

Developing with BDNF: a moving experience.

Author information

1
Cell Biology Program, Hospital for Sick Children, Toronto, M5G 1L7 ON, Canada. dkaplan@sickkids.ca

Abstract

During development, newly born neurons migrate away from their initial birth sites to their final positions in the mature brain. The neurotrophin BDNF has been shown to regulate the migration of granule cells in the cerebellum. The cellular mechanisms that mediate this chemotactic response have not been resolved. In this issue of Neuron, Zhou et al. show that vesicle trafficking is critical for allowing neurons to respond to a gradient of BDNF.

PMID:
17610810
DOI:
10.1016/j.neuron.2007.06.025
[Indexed for MEDLINE]
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