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Org Biomol Chem. 2007 Jul 21;5(14):2211-3. Epub 2007 Jun 18.

A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex.

Author information

1
Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11 a, D-07745 Jena, Germany.

Abstract

Targeted gene inactivation and metabolic profiling revealed that the cryptic PKS-NRPS gene cluster in the genome of the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of antiproliferative and antifungal rhizoxin derivatives.

PMID:
17609750
DOI:
10.1039/b707762a
[Indexed for MEDLINE]

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