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J Neuroimmunol. 2007 Sep;189(1-2):125-8. Epub 2007 Jul 3.

The role of VLA4 polymorphisms in multiple sclerosis: an association study.

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Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy.


Lymphocyte and monocyte brain infiltration determines inflammation in multiple sclerosis. The trafficking of these cells into the CNS results from the VLA-4 binding with its ligand on brain endothelial cells. MS patients treated with an antibody against the alpha-4 subunit, which inhibits this interaction, prevents brain lesion development. We investigated the association between VLA-4 gene polymorphisms and MS in a study on 275 patients and 255 controls. No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy.

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