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J Neuroimmunol. 2007 Sep;189(1-2):125-8. Epub 2007 Jul 3.

The role of VLA4 polymorphisms in multiple sclerosis: an association study.

Author information

1
Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy. v.andreoli@isn.cnr.it

Abstract

Lymphocyte and monocyte brain infiltration determines inflammation in multiple sclerosis. The trafficking of these cells into the CNS results from the VLA-4 binding with its ligand on brain endothelial cells. MS patients treated with an antibody against the alpha-4 subunit, which inhibits this interaction, prevents brain lesion development. We investigated the association between VLA-4 gene polymorphisms and MS in a study on 275 patients and 255 controls. No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy.

PMID:
17609118
DOI:
10.1016/j.jneuroim.2007.06.015
[Indexed for MEDLINE]

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