Efficient synthesis of the 3-benzazepine framework via intramolecular Heck reductive cyclization

Org Lett. 2007 Aug 2;9(16):3017-20. doi: 10.1021/ol071079g. Epub 2007 Jul 3.

Authors

Pavel A Donets¹, Erik V Van der Eycken

Affiliation

¹ Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.

PMID: 17608431
DOI: 10.1021/ol071079g

Abstract

A microwave-assisted protocol based on reductive Heck reaction was developed for regio- and stereoselective construction of the 3-benzazepine core.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemical synthesis*
Alkaloids / chemistry
Benzazepines / chemical synthesis*
Benzazepines / chemistry
Combinatorial Chemistry Techniques
Cyclization
Microwaves
Molecular Structure
Oxidation-Reduction
Stereoisomerism

Substances

Alkaloids
Benzazepines