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Int J Pharm. 2007 Aug 1;340(1-2):1-5. Epub 2007 May 26.

Effect of the combination of organic and inorganic filters on the Sun Protection Factor (SPF) determined by in vitro method.

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Université de Nantes, Nantes Atlantique Universités, LPiC, SMAB, EA2160, Faculty of Pharmacy, 1 rue G. Veil - BP 53508, Nantes F-44000, France.


This paper describes the effect on Sun Protection Factor (SPF) of the combination of inorganic and organic filters in sunscreen products as determined by an in vitro method. O/W emulsions containing inorganic filters, such as titanium dioxide and zinc oxide, combined with 18 EU-authorized UV-B organic filters were tested. SPF measurements were carried out using a spectrophotometer equipped with an integrating sphere. This study observed a synergic effect when titanium dioxide was combined with either anisotriazine or octyldimethylPABA. The combination of zinc oxide with 11 UV-B organic filters also exhibited a similar synergy; however, the measured SPF was systematically lower than the protection factor achieved with titanium dioxide.

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