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Cell Mol Life Sci. 2007 Sep;64(17):2202-10.

Causes of oxidative stress in Alzheimer disease.

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1
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.

Abstract

Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.

PMID:
17605000
DOI:
10.1007/s00018-007-7218-4
[Indexed for MEDLINE]
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