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Cell. 2007 Jun 29;129(7):1261-74.

AKT/PKB signaling: navigating downstream.

Author information

1
Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2-117, Boston, MA 02115, USA. bmanning@hsp.harvard.edu

Abstract

The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer. Here, we review the molecular properties of Akt and the approaches used to characterize its true cellular targets. In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration.

PMID:
17604717
PMCID:
PMC2756685
DOI:
10.1016/j.cell.2007.06.009
[Indexed for MEDLINE]
Free PMC Article
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