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Cell. 2007 Jun 29;129(7):1257-9.

HOTAIR lifts noncoding RNAs to new levels.

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1
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

It is not clear to what extent noncoding RNAs regulate the homeobox (HOX) genes that encode key regulators of development in the embryo. In this issue, Rinn et al. (2007) characterize noncoding RNAs that regulate HOX genes and discover one, HOTAIR, that unexpectedly regulates a HOX gene cluster on a different chromosome than the HOX cluster that encodes it.

PMID:
17604716
DOI:
10.1016/j.cell.2007.06.014
[Indexed for MEDLINE]
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