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Cell. 2007 Jun 29;129(7):1255-7.

The primary cilium: keeper of the key to cell division.

Author information

1
Department of Biological Sciences and Technologies, Tsinghua University, Haidian District, Beijing, 100084, China.

Abstract

Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

PMID:
17604715
DOI:
10.1016/j.cell.2007.06.018
[Indexed for MEDLINE]
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