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Cell. 2007 Jun 29;129(7):1244-7.

Immortal strands? Give me a break.

Author information

1
Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada. plansdor@bccrc.ca

Abstract

The "immortal strand" hypothesis proposes that asymmetrically dividing stem cells selectively retain chromosomes containing "old" DNA to prevent accumulation of mutations. As I describe in this Essay, such a possibility seems unlikely. An alternative explanation is that asymmetric cell divisions and cell fate are codirected by epigenetic differences between sister chromatids.

PMID:
17604711
DOI:
10.1016/j.cell.2007.06.017
[Indexed for MEDLINE]
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