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Trans R Soc Trop Med Hyg. 2007 Oct;101(10):1042-4. Epub 2007 Jun 29.

Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception?

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1
Faculty of Medicine, São José do Rio Preto, Av. Brigadeiro Faria Lima 5416, 15090-000 São José do Rio Preto, São Paulo State, Brazil. cecavasini@famerp.br

Abstract

We present evidence for Plasmodium vivax infection among Duffy blood group-negative inhabitants of Brazil. The P. vivax identification was determined by both genotypic and non-genotypic screening tests. The Duffy blood group was genotyped by PCR/RFLP and phenotyped using a microtyping kit. We detected two homozygous FY*B-33 carriers infected by P. vivax, whose circumsporozoite protein genotypes were VK210 and/or P. vivax-like. Additional efforts are necessary in order to clarify the evidence that P. vivax is being transmitted among Duffy blood group-negative patients from the Brazilian Amazon region.

PMID:
17604067
DOI:
10.1016/j.trstmh.2007.04.011
[Indexed for MEDLINE]
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