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Photomed Laser Surg. 2007 Jun;25(3):180-2.

Ga-As (808 nm) laser irradiation enhances ATP production in human neuronal cells in culture.

Author information

1
Photothera Inc., Carlsbad, California, USA. oronu@post.tau.ac.il

Abstract

OBJECTIVE:

The aim of the present study was to investigate whether Ga-As laser irradiation can enhance adenosine triphosphate (ATP) production in normal human neural progenitor (NHNP) cells in culture.

METHODS:

NHNP were grown in tissue culture and were treated by Ga-As laser (808 nm, 50 mW/cm(2), 0.05 J/cm(2)), and ATP was determined at 10 min after laser application.

RESULTS:

The quantity of ATP in laser-treated cells was 7513 +/- 970 units, which was significantly higher (p < 0.05) than the non-treated cells, which comprised 3808 +/- 539 ATP units.

CONCLUSION:

Laser application to NHNP cells significantly increases ATP production in these cells. These findings may explain the beneficial effects of low-level laser therapy (LLLT) in stroked rats. Tissue culture of NHNP cells might offer a good model to study the mechanisms associated with promotion of ATP production in the nervous system by LLLT.

PMID:
17603858
DOI:
10.1089/pho.2007.2064
[Indexed for MEDLINE]

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