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Nat Neurosci. 2007 Aug;10(8):949-51. Epub 2007 Jul 1.

Cocaine-induced decision-making deficits are mediated by miscoding in basolateral amygdala.

Author information

1
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St., HSF-2 S251, Baltimore, Maryland 21201, USA. tstal002@umaryland.edu

Abstract

Addicts and drug-experienced animals have decision-making deficits in reversal-learning tasks and more complex 'gambling' variants. Here we show evidence that these deficits are mediated by persistent encoding of outdated associative information in the basolateral amygdala. Cue-selective neurons in the basolateral amygdala, recorded in cocaine-treated rats, failed to change cue preference during reversal learning. Further, the presence of these neurons was critical to the expression of the reversal-learning deficit in the cocaine-treated rats.

PMID:
17603478
PMCID:
PMC2562677
DOI:
10.1038/nn1931
[Indexed for MEDLINE]
Free PMC Article

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