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Best Pract Res Clin Rheumatol. 2007 Jun;21(3):499-511.

Pharmacological treatment of fibromyalgia and other chronic musculoskeletal pain.

Author information

1
Newton-Wellesley Hospital, Division of Rheumatology, Newton, MA 02468, USA. dgoldenb@massmed.org

Abstract

The pharmacologic management of fibromyalgia is based on the emerging evidence that pain in this disorder is primarily related to central pain sensitization. There is strong evidence that tricyclic antidepressants are effective, and moderate evidence for the effectiveness of serotonin reuptake inhibitors and dual serotonin-norepinephrine reuptake inhibitors. Recent work suggests that the anti-seizure medications pregabalin and gabepentin are also effective. The only analgesic demonstrated to be helpful is tramadol.

PMID:
17602996
DOI:
10.1016/j.berh.2007.02.012
[Indexed for MEDLINE]

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