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Expert Opin Investig Drugs. 2007 Jul;16(7):1111-20.

Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma.

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University of Texas MD Anderson Cancer Center, Department of Dermatology, Houston, TX 77030, USA.


Epigenetic regulation of gene transcription by small-molecule inhibitors of histone deacetylases (HDACs) is a novel cancer therapy. Vorinostat (suberoylanilide hydroxamic acid) is the first FDA-approved HDAC inhibitor for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL). Vorinostat was active against solid tumors and hematologic malignancies as intravenous and oral preparations in Phase I development. In two Phase II trials, vorinostat 400 mg/day was safe and effective with an overall response rate of 24-30% in refractory advanced patients with CTCL including large cell transformation and S├ęzary syndrome. The common side effects of vorinostat, which are similar in all studies, include gastrointestinal symptoms, fatigue and thrombocytopenia and the most common serious event was thrombosis.

[Indexed for MEDLINE]

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