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Intensive Care Med. 2007 Sep;33(9):1563-70. Epub 2007 Jun 27.

Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators.

Author information

1
Jikei University School of Medicine, Intensive Care Unit, Department of Anesthesiology, Tokyo, Japan.

Abstract

OBJECTIVE:

Little information is available regarding current practice in continuous renal replacement therapy (CRRT) for the treatment of acute renal failure (ARF) and the possible clinical effect of practice variation.

DESIGN:

Prospective observational study.

SETTING:

A total of 54 intensive care units (ICUs) in 23 countries.

PATIENTS AND PARTICIPANTS:

A cohort of 1006 ICU patients treated with CRRT for ARF.

INTERVENTIONS:

Collection of demographic, clinical and outcome data.

MEASUREMENTS AND RESULTS:

All patients except one were treated with venovenous circuits, most commonly as venovenous hemofiltration (52.8%). Approximately one-third received CRRT without anticoagulation (33.1%). Among patients who received anticoagulation, unfractionated heparin (UFH) was the most common choice (42.9%), followed by sodium citrate (9.9%), nafamostat mesilate (6.1%), and low-molecular-weight heparin (LMWH; 4.4%). Hypotension related to CRRT occurred in 19% of patients and arrhythmias in 4.3%. Bleeding complications occurred in 3.3% of patients. Treatment with LMWH was associated with a higher incidence of bleeding complications (11.4%) compared to UFH (2.3%, p = 0.0083) and citrate (2.0%, p = 0.029). The median dose of CRRT was 20.4 ml/kg/h. Only 11.7% of patients received a dose of > 35 ml/kg/h. Most (85.5%) survivors recovered to dialysis independence at hospital discharge. Hospital mortality was 63.8%. Multivariable analysis showed that no CRRT-related variables (mode, filter material, drug for anticoagulation, and prescribed dose) predicted hospital mortality.

CONCLUSIONS:

This study supports the notion that, worldwide, CRRT practice is quite variable and not aligned with best evidence.

PMID:
17594074
DOI:
10.1007/s00134-007-0754-4
[Indexed for MEDLINE]

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