Format

Send to

Choose Destination
See comment in PubMed Commons below
Lab Chip. 2007 Jul;7(7):856-62. Epub 2007 May 2.

Surface modification of thermoplastics--towards the plastic biochip for high throughput screening devices.

Author information

1
Industrial Materials Institute, National Research Council of Canada, 75 de Mortagne, Boucherville, QC, Canada. gerardo.diaz@cnrc-nrc.gc.ca

Abstract

Microarrays have become one of the most convenient tools for high throughput screening, supporting major advances in genomics and proteomics. Other important applications can be found in medical diagnostics, detection of biothreats, drug discovery, etc. Integration of microarrays with microfluidic devices can be highly advantageous in terms of portability, shorter analysis time and lower consumption of expensive biological analytes. Since fabrication of microfluidic devices using traditional materials such as glass is rather expensive, there is great interest in employing polymeric materials as a low cost alternative that is suitable for mass production. A number of commercially available plastic materials were reviewed for this purpose and poly(methylmethacrylate) Zeonor 1060R and Zeonex E48R were identified as promising candidates, for which methods for surface modification and covalent immobilization of DNA oligonucleotides were developed. In addition, we present proof-of-concept plastic-based microarrays with and without integration with microfluidics.

PMID:
17594004
DOI:
10.1039/b700322f
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Support Center