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Hepatogastroenterology. 2007 Apr-May;54(75):910-2.

Treatment response in liver metastases following 90Y SIR-spheres: an evaluation with PET.

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Department of Nuclear Medicine, PET and Clinical Ultrasound, Liverpool Hospital, 1 Elizabeth Drive, Liverpool, NSW 2170, Australia.


Selective internal radiation therapy (SIRT) with radiolabeled Yttrium-90 (90Y) microspheres is a relatively new therapeutic option for patients with primary or secondary hepatic malignancy. However, the evaluation of the therapeutic efficacy on anatomic imaging alone is suboptimal. Functional imaging with F18-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) is increasingly utilised in therapy monitoring in malignancy and provides an accurate assessment of metabolic response. We report a case of a 75-year-old gentleman with colorectal hepatic metastases who demonstrated a dramatic metabolic response on PET scan following SIRT. This case illustrates the utility of FDG PET in the assessment of the therapeutic efficacy of 90Y microspheres in colorectal hepatic metastases.

[Indexed for MEDLINE]

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