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Virology. 2007 Oct 10;367(1):156-67. Epub 2007 Jun 27.

Multiple immunizations with adenovirus and MVA vectors improve CD8+ T cell functionality and mucosal homing.

Author information

1
The Wistar Institute, Philadelphia, PA, USA. tatsis@wistar.org

Abstract

Recombinant adenovirus vectors and MVA vectors were used in prime boost vaccine regimens to address the impact of repeated immunizations on transgene product-specific CD8(+) T cell frequencies, phenotypes, function, and localization. We show that a regimen with three immunizations incorporating MVA, human adenovirus serotype 5 and chimpanzee-derived adenoviruses serotype 68 or 7 yields high transgene product-specific CD8(+) T cell frequencies in spleen, blood, lymph nodes, and peritoneal lavage. Furthermore, upon triple immunization increased frequencies of transgene-specific T cells were measured at mucosal sites such as mesenteric lymph nodes, intestinal epithelium, and Peyer's patches. Multiple dose vaccine regimens that markedly increase functionally active transgene-specific T cells and target them to the appropriate ports of entry may be important in protection against pathogens such as HIV-1.

PMID:
17590405
PMCID:
PMC2043483
DOI:
10.1016/j.virol.2007.05.028
[Indexed for MEDLINE]
Free PMC Article
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