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Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15;31(6):1275-81. Epub 2007 May 26.

5-HT2A SNPs and the Temperament and Character Inventory.

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1
Institute of Psychiatry University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy. alessandro.serretti@unibo.it

Abstract

Temperamental traits, the most basic part of personality, have been largely correlated with neurotransmitter systems and are under genetic control. Among serotonin candidates, the 2A receptor (5-HT(2A)) received considerable attention. We analyzed four SNPs (rs643627, rs594242, rs6311 and rs6313) in the 5-HT(2A) gene and their association with personality traits, as measured with the Temperament and Character Inventory (TCI). The sample was composed of three sub-groups: two German sub-samples, consisting of a healthy group of 289 subjects (42.6% males, mean age: 45.2+/-14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2+/-13.6), and an Italian sub-sample, composed of 60 mood disorder patients (35.0% males, mean age: 44.0+/-14.8). Controlling for sex, age and educational level, the SNPs were not strongly associated with personality dimensions. Only the rs594242 showed an association with Self-Directedness (p=0.003) in the German sample, while rs6313 was marginally associated with Novelty Seeking (p=0.01) in the Italian sample. We conclude that 5-HT(2A) SNPs may marginally modulate personality traits but further studies are required.

PMID:
17590256
DOI:
10.1016/j.pnpbp.2007.05.008
[Indexed for MEDLINE]
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