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FEBS Lett. 2007 Jul 10;581(17):3164-70. Epub 2007 Jun 12.

The maximal size of protein to diffuse through the nuclear pore is larger than 60kDa.

Author information

1
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. ruiwenwang@gmail.com

Abstract

It has generally been believed that the diffusion limit set by the nuclear pore for protein is 60kDa. We here studied the cellular localization of several artificial proteins and found that the diffusion limit set by the nuclear pore is not as small as previously thought. The results indicate that the maximal size of protein to diffuse through the nuclear pore complex could be quite larger than 60kDa, thus greatly extending the diffusion limit that the nuclear pore can accommodate.

PMID:
17588566
PMCID:
PMC4064367
DOI:
10.1016/j.febslet.2007.05.082
[Indexed for MEDLINE]
Free PMC Article

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