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Inflamm Res. 2007 May;56(5):210-5.

Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line.

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1
Department of Surgery, Chosun University Medical School, Gwangju, 501-759, Republic of Korea.

Abstract

OBJECTIVE AND DESIGN:

Mast cell-mediated allergic inflammation is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1.

METHODS:

HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI).

RESULTS:

Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin attenuated PMACI-induced activation of NF-kappaB and p38 mitogen-activated protein kinase.

CONCLUSION:

Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic inflammatory diseases.

PMID:
17588137
DOI:
10.1007/s00011-007-6172-9
[Indexed for MEDLINE]
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