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Skin Pharmacol Physiol. 2007;20(5):253-9. Epub 2007 Jun 22.

Functional assessment of a skin care system in patients on chemotherapy.

Author information

  • 1Skin Physiology Laboratory, Friedrich-Schiller University, Jena, Germany. Fluhr@derma.uni-jena.de

Abstract

BACKGROUND/PURPOSE:

Cancer patients undergoing chemotherapy frequently experience skin problems such as xerosis. The aim of this study was to verify whether a concomitant treatment with an acidic washing and an acidic emollient (both pH 5.5) can significantly improve the quality of the skin in such patients.

METHODS:

30 adult patients on chemotherapy experiencing dry and sensitive skin were included in a controlled, monocentric, 3-week treatment trial. One forearm served as a test site, the other one remained untreated. Noninvasive biophysical measurements were performed at baseline, on days 7, 14 and 21, along with clinical evaluation of the skin symptoms.

RESULTS:

After a 3-week treatment, a significant increase in stratum corneum hydration was recorded in the treated site (p < 0.001). Reduced transepidermal water loss values, consistent with a restored barrier function, were obtained (p < 0.001). Casual sebum levels as measured by sebumetry showed a significant increase (p < 0.03). All skin symptoms investigated revealed a considerable improvement over 3 weeks.

CONCLUSION:

Controlled and regular use of a skin care system, especially an acidic one, improved skin physiology in patients undergoing chemotherapy.

PMID:
17587889
DOI:
10.1159/000104423
[PubMed - indexed for MEDLINE]
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