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Trends Microbiol. 2007 Aug;15(8):335-8. Epub 2007 Jun 22.

Actinomycete-like proteasomes in a Gram-negative bacterium.

Author information

1
Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, B-3001 Heverlee-Leuven, Belgium. rene.demot@biw.kuleuven.be

Abstract

Cultivation-independent proteogenomic exploration of mine-drainage biofilm has revealed proteasomes in Gram-negative bacteria of the Nitrospirae phylum (Leptospirillum group II) dominating this acidophilic community. Most probably, the proteasome genes were acquired from actinobacteria, the only eubacteria previously known to contain proteasomes. In addition, this study shows that the proteasome and the evolutionarily related ATP-dependent protease HslVU (also known as ClpQY) are not mutually exclusive in prokaryotes.

PMID:
17587582
DOI:
10.1016/j.tim.2007.06.002
[Indexed for MEDLINE]

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