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Bioorg Med Chem Lett. 2007 Sep 1;17(17):4901-5. Epub 2007 Jun 13.

Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators.

Author information

1
Argenta Discovery Ltd, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, UK. nick.ray@argentadiscovery.com

Abstract

A virtual screening approach comprising a 3-D similarity search based on known GR modulators was used to identify a novel series of non-steroidal glucocorticoid receptor (GR) antagonists. Optimization of the initial hit to provide potent compounds which exhibit good selectivity against other steroidal nuclear hormone receptors is described.

PMID:
17587578
DOI:
10.1016/j.bmcl.2007.06.036
[Indexed for MEDLINE]

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