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Bioorg Med Chem Lett. 2007 Sep 1;17(17):4938-41. Epub 2007 Jun 14.

Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.

Author information

1
Department of Chemistry, University of California, Berkeley, CA 94720, USA.

Abstract

Soluble guanylate cyclase (sGC) is activated by the known benzylindazole derivative YC-1 [1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole]. YC-1 also acts synergistically with CO, activating sGC to a level comparable to that achieved upon binding of nitric oxide, the endogenous activator of sGC. We here describe the synthesis of a YC-1 phosphonate analogue with improved aqueous solubility as well as its effects on sGC.

PMID:
17587571
DOI:
10.1016/j.bmcl.2007.06.039
[Indexed for MEDLINE]

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