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Dev Growth Differ. 2007 Aug;49(6):421-37. Epub 2007 Jun 24.

Early steps of paired fin development in zebrafish compared with tetrapod limb development.

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European Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany.


The development of zebrafish paired fins and tetrapod forelimbs and hindlimbs show striking similarities at the molecular level. In recent years, the zebrafish, Danio rerio has become a valuable model for the study of the development of vertebrate paired appendages and several large-scale mutagenesis screens have identified novel fin mutants. This review summarizes recent advances in research into zebrafish paired fin development and highlights features that are shared with and distinct from limb development in other main animal models.

[Indexed for MEDLINE]

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