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Trends Parasitol. 2007 Aug;23(8):341-3. Epub 2007 Jun 22.

Predicting memory: a prospective readout for malaria vaccines?

Author information

1
Department of Immunology, Monash University, The Alfred Medical Research and Education Precinct, Prahran, Victoria 3181, Australia.

Abstract

Malaria vaccines aim to induce long lasting protective immunity. Bejon and colleagues propose that levels of rapidly induced (effector memory) interleukin-2 and interferon gamma producing T-cells after vaccination with leading pre-erythrocytic stage vaccines predict the induction of resting memory responses (central memory). Herein we discuss Bejon's findings in the context of current thinking on the generation and maintenance of T cell memory, with particular emphasis on the role of cytokines.

PMID:
17586093
DOI:
10.1016/j.pt.2007.06.006
[Indexed for MEDLINE]

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