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Nat Rev Cancer. 2007 Jul;7(7):519-30.

Calcium and cancer: targeting Ca2+ transport.

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School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia, 4072.


Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?

[Indexed for MEDLINE]

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