A search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins

Mini Rev Med Chem. 2007 Jun;7(6):609-16. doi: 10.2174/138955707780859422.

Abstract

Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium-Binding Proteins / antagonists & inhibitors*
  • Databases, Genetic
  • Feedback, Physiological
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Nerve Growth Factors / antagonists & inhibitors*
  • Nerve Growth Factors / chemistry
  • Nerve Growth Factors / genetics
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins / antagonists & inhibitors*
  • S100 Proteins / chemistry
  • S100 Proteins / genetics
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / physiology

Substances

  • Calcium-Binding Proteins
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • S100B protein, human
  • Tumor Suppressor Protein p53
  • Calcium