Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Top Med Chem. 2007;7(12):1195-204.

Strategies for the design of non-peptide CCK2 receptor agonist and antagonist ligand.

Author information

1
James Black Foundation, Dulwich, London, UK. barret.kalindjian@kcl.ac.uk

Abstract

There has been an effort towards the design and preparation of non-peptide antagonists of the CCK(2) receptor going back for over fifteen years. However, as no obvious unmet medical need for this type of molecule has emerged, the interest has somewhat declined. A number of comprehensive reviews have been written where much of the early work is described and so this article focuses on the information generated in the last five years. It is to be hoped that the area will regain some impetus following the recent disclosure of clinical trial data demonstrating the possible utility of a CCK(2) antagonist in pancreatic cancer. When considering non-peptide agonists for the CCK(2) receptor, traditionally, much less work has been reported in the area. However, recent suggestions of possible clinical utility in the treatment of diabetes, functionally different subtypes of the receptor and molecular models of receptor-ligand interactions should act as a spur for work towards potent small molecule ligands.

PMID:
17584141
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Bentham Science Publishers Ltd.
    Loading ...
    Support Center