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Eur J Med Chem. 2008 Mar;43(3):513-39. Epub 2007 May 6.

Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor.

Author information

1
Department of Medicinal Chemistry, Victorian College of Pharmacy (Monash University), 381 Royal Parade Parkville, Victoria, 3052, Australia. gerard.moloney@vcp.monash.edu.au

Abstract

An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB(1) agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of a series of 1-substituted-indole-3-oxadiazoles as potential CB(1) agonists.

PMID:
17582659
DOI:
10.1016/j.ejmech.2007.04.007
[Indexed for MEDLINE]

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